Abstract: The Nelder-Mead simplex method is a well-known algorithm enabling the minimization of functions that are not available in closed-form and that need not be differentiable or convex.

Everyone should care about privacy and security of their communications - innocuous conversations can put you in danger even if there is nothing to hide. One of the most shocking stories is the ...

Our choice for the 2020 Method of the Year is spatially resolved transcriptomics. The cover depicts an example of data generated by spatially resolved transcriptomics technology. Middle layer: ...

Abstract: A novel, tuning-free, population-based simplex method for continuous function optimization is proposed. The proposed method, called Adaptive Population-based Simplex (APS), uses a population ...